Cannabigerol

Biosynthesis

Biosynthesis of cannabigerol

The biosynthesis of cannabigerol begins by loading hexanoyl-CoA onto a polyketide synthase assembly protein and subsequent condensation with three molecules of malonyl-CoA. This polyketide is cyclized to olivetolic acid via olivetolic acid cyclase, and then prenylated with a ten carbon isoprenoid precursor, geranyl pyrophosphate, using an aromatic prenyltransferase enzyme, geranyl-pyrophosphate—olivetolic acid geranyltransferase, to biosynthesize cannabigerolic acid, which can then be decarboxylated to yield cannabigerol.

Research

As of 2019, no clinical research has been conducted to test the specific effects of cannabigerol in humans.

Cannabigerol is under laboratory research to determine its pharmacological properties and potential effects in disease conditions. Contrary to the major psychoactive cannabinoid THC, cannabigerol antagonizes CB1 receptors and is both an alpha2-adrenoceptor agonist and moderate 5HT1A receptor antagonist. Cannabigerol displays CB1 and CB2 binding affinity, and has been evaluated in laboratory models of colitis.

Legal status

Cannabigerol is not scheduled by the UN Convention on Psychotropic Substances.[citation needed] In the United States, it is not a named controlled substance under the Controlled Substances Act.

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